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Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart
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Subendocardial ischemia without coronary artery disease: is elevated left ventricular end diastolic pressure the

Abdul-Karim Elhabyan1, Bernardo J Reyes, Omar Hallak

  • 1CAMC Health Education and Research Institute, West Virginia University, Charleston Area Medical Center, Charleston, West Virginia 25304, USA.

Current Medical Research and Opinion
|May 14, 2004
PubMed

Insights

Elevated left ventricular end diastolic pressure (LVEDP) is associated with subendocardial ischemia in patients without significant coronary artery disease. Abnormal LVEDP increases the likelihood of a positive stress test, indicating potential ischemia.

Area of Science:

  • Cardiology
  • Diagnostic Imaging

Background:

  • Investigating the link between elevated left ventricular end diastolic pressure (LVEDP) and subendocardial ischemia.
  • Understanding ischemia indicators in patients with chest pain and non-significant coronary artery disease (CAD).

Purpose of the Study:

  • To determine the association between elevated LVEDP and subendocardial ischemia.
  • To assess if LVEDP can predict positive stress test results in specific patient groups.

Main Methods:

  • Retrospective chart review of 1846 patients admitted with chest pain.
  • Analysis of stress testing and coronary angiography results.
  • Comparison of LVEDP in patients with positive vs. negative stress tests and non-significant CAD.

Main Results:

  • A study group (n=210) with positive stress tests and non-significant CAD had a mean LVEDP of 11.8 mmHg, significantly higher than the control group (n=44) with a mean LVEDP of 7.8 mmHg (p < 0.001).
  • Abnormal LVEDP (>= 12 mmHg) was more prevalent in the study group (49.05%) than the control group (22.73%) (p < 0.001).
  • Logistic regression indicated patients with abnormal LVEDP were 11 times more likely to have a positive stress test.

Conclusions:

  • A positive association exists between elevated LVEDP and subendocardial ischemia.
  • Elevated LVEDP may serve as a marker for ischemia in patients without significant CAD, manifesting as a positive stress test.
Abstract

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