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p53 at codon 72 polymorphism, human papillomavirus infection and cervical lesions: a cross-sectional study from
Manola Comar1, Gianna Dal Molin, Secondo Guaschino
1Department of Public Medicine Sciences, U.C.O. Hygiene and Preventive Medicine, University of Trieste, I.R.C.C.S. Burlo Garofolo, Via dell'Istria 65/1, Trieste 34100, Italy. comar@burlo.trieste.it
Objective:
To test the hypothesis that p53 homozygous Arg/Arg genotype at codon 72 is a significant risk factor for the development of HPV induced cervical cancer.
Study Design:
A cross-sectional survey on p53 allelotypes distribution in women with different grade of cervical lesions and with or without HPV infection, in comparison to the distribution on a control group of women cytologically normal and HPV negative.
Results:
No statistically significant difference in the p53 polymorphism distribution was found in relation to the infection with HPV, the cytological pattern and both conditions. A modest but constant over-representation of Pro-allelotypes was found in all groups in comparison to the control group.
Conclusion:
Searching for p53 polymorphism in a clinical setting does not seem to support secondary prevention procedures, at least for women in this area.
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