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Published on: February 3, 2022
Morphological and morphometric characteristics of choroid plexus psammoma bodies during the human aging
Ivan Jovanović1, Natalija Stefanović, Svetlana Antić
1Depatment of Anatomy, Medical Faculty Nis, Serbia and Montenegro. ivanjov@junis.ni.ac.yu
Abstract:
Psammoma bodies are one of many choroid plexus aging changes which origin is still enigma for the scientists. During our investigation psammoma bodies were studied on 30 postmortem brains by light microscopy. They stained red with HE, and were PAS and AB PAS positive. The largest number of lamellas were stained blue with Mallory's connective tissue stain, except peripheral and next to the center lamella which stained red. During the aging, psammoma bodies became larger and more irregular, which was followed with group area and perimeter, single psammoma body average area and average perimeter, average diameter and contour index increase. Psammoma bodies mearged in the second and the third age group and mearging process led to larger and more irregular structures formation. The results of this investigation suggest that psammoma bodies are more frequent in choroid plexus of healthy older people and during the aging they obtain larger dimensions, more irregular contours, which is the result of their mutual mearging.
Insights
Psammoma bodies in the choroid plexus increase in size and irregularity with age. These aging changes are more common in healthy older individuals due to merging.
Area of Science:
- Neuropathology
- Aging research
- Histology
Background:
- Psammoma bodies are observed in choroid plexus aging.
- Their origin remains unclear.
- Choroid plexus aging involves various changes.
Purpose of the Study:
- To investigate the characteristics and changes of psammoma bodies during aging.
- To analyze the morphological alterations and prevalence of psammoma bodies in postmortem brains.
Main Methods:
- Light microscopy was used to examine psammoma bodies in 30 postmortem brains.
- Histochemical staining (HE, PAS, AB PAS, Mallory's connective tissue stain) was applied.
- Morphometric analysis (area, perimeter, diameter, contour index) was performed.
Main Results:
- Psammoma bodies showed specific staining patterns with HE, PAS, AB PAS, and Mallory's stain.
- With aging, psammoma bodies increased in size and irregularity.
- Merging of psammoma bodies was observed in older age groups, forming larger structures.
Conclusions:
- Psammoma bodies are frequent in the choroid plexus of healthy older individuals.
- Aging leads to increased size and irregular contours of psammoma bodies.
- The merging of psammoma bodies contributes to their altered morphology in aging individuals.
