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Reconstruction of mastoid cortex defect using bone morphogenetic protein: an experimental study in the guinea pig
Akira Sugimoto1, Nobuhiro Hakuba, Kiyofumi Gyo
1Department of Otolaryngology, Head and Neck Surgery, Ehime University School of Medicine, Onsen-gun, Ehime, Japan. sugimoto@m.ehime-u.ac.jp
Objective:
The aim of this experimental study was to examine whether recombinant human bone morphogenetic protein-2 (rhBMP-2) could induce new bone formation in a small hole drilled through the temporal bone near the external auditory canal wall in guinea pigs.
Material And Methods:
A 4-mm diameter hole was made in the center of the temporal bone and a piece of collagen sheet infiltrated with rhBMP-2 was placed in the hole. New bone formation was confirmed by means of X-ray examination and the bone mineral density was quantified using dual-energy X-ray absorptiometry 1, 2 and 4 weeks after treatment.
Results:
The bone mineral density in the rhBMP-2-treated group was significantly increased compared to the control group.
Conclusion:
These results suggest that rhBMP-2 induces remarkable new bone formation in the temporal bone and will be useful in clinical ear surgery.
