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Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

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Published on: December 16, 2022

Chronic circadian misalignment accelerates sarcopenia progression in mice.

Takashi Seya^1,2, Nobuya Koike¹, Naoki Okubo^1,2

¹Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Frontiers in Physiology

|December 1, 2025

Summary

Chronic jet lag accelerates muscle loss and weakness, indicating circadian misalignment is a risk factor for sarcopenia. This highlights circadian rhythms as a target for preventing age-related muscle decline.

Keywords:

TWEAK/Fn14 signaling circadian misalignment circadian rhythm frailty sarcopenia skeletal muscle

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Area of Science:

Chronobiology
Muscle Physiology
Aging Research

Background:

Circadian misalignment from lifestyle factors is linked to adverse health outcomes.
Sarcopenia, the loss of muscle strength and mass, is a growing public health concern.
The relationship between circadian disruption and sarcopenia is not well understood.

Purpose of the Study:

To investigate the impact of chronic circadian misalignment on skeletal muscle health.
To determine if chronic jet lag induces sarcopenia-like changes in mice.

Main Methods:

Mice were subjected to chronic jet lag (ADV group) or a fixed light-dark cycle (LD group) for 64 weeks.
Grip strength, hindlimb muscle weight, and muscle histology were assessed.
Transcriptomic analysis of hindlimb muscles was performed.

Main Results:

Chronic jet lag significantly reduced grip strength and muscle weight.
Histological and transcriptomic analyses revealed sarcopenia hallmarks, including TWEAK/Fn14 signaling activation and reduced myofiber size.
Evidence of compensatory muscle regeneration was observed but insufficient to prevent atrophy.

Conclusions:

Circadian misalignment is a potential risk factor for sarcopenia.
Circadian rhythms are critical regulators of muscle health and represent a target for sarcopenia prevention strategies.