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Updated: Aug 24, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

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[Pott's disease and different clinical presentations Pott's disease and different clinical presentations]

A Berna Dursun1, Z Müjgan Güler, Kivanç Budak

  • 1Atatürk Research and Educational Centre Chest Medicine and Thoracic Surgery, Ankara, Turkey. ebdursun@superonline.com

Tuberkuloz Ve Toraks
|May 15, 2004
PubMed

Insights

Spinal tuberculosis, a significant cause of bone and joint disease, often affects young adults. Early diagnosis and pharmacological treatment are crucial for managing spinal tuberculosis and preventing complications.

Area of Science:

  • Orthopedics
  • Infectious Diseases
  • Radiology

Background:

  • Skeletal tuberculosis is a debilitating condition, disproportionately affecting young populations in developing regions.
  • The spine is a common site for osteoarticular tuberculosis, accounting for approximately 50% of cases.
  • Early detection and management are vital to prevent severe outcomes.

Observation:

  • This study reviewed four immunocompetent adult male cases of spinal tuberculosis (ages 18-76).
  • The primary symptom was pain, with no critical neurological deficits observed.
  • Case presentations included upper cervical-lower thoracic and thoracolumbar involvement, with associated psoas abscesses, peritoneal tuberculosis, and varied pulmonary tuberculosis presentations (miliary, chronic, new).

Findings:

  • Diagnosis was confirmed using Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) scans.
  • All patients received specific antitubercular therapy and supportive care.
  • Remarkable clinical improvement was observed in three cases without surgical intervention, while one case with miliary pulmonary tuberculosis showed a less favorable response.

Implications:

  • The findings underscore the importance of early diagnosis of spinal tuberculosis.
  • Prompt initiation of pharmacological treatment can lead to significant recovery and help avoid surgical interventions.
  • This highlights the need for timely medical intervention to mitigate the severity of skeletal tuberculosis.

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