Related Experiment Video
Updated: Jul 12, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma
H Jongepier1, H M Boezen, A Dijkstra
1Department of Pulmonary Diseases, University Hospital, Groningen, The Netherlands.
Genetic variants in the ADAM33 gene are linked to faster lung function decline in asthma patients. This suggests ADAM33 plays a role in asthma progression and airway remodeling.
Area of Science:
- Genetics
- Pulmonology
- Molecular Biology
Background:
- Asthma is a complex respiratory disease involving inflammation and airway remodeling.
- The ADAM33 gene is implicated in asthma development and airway hyper-responsiveness.
- ADAM33 is hypothesized to be a key factor in airway remodeling processes.
Purpose of the Study:
- To determine if ADAM33 gene polymorphisms correlate with accelerated lung function decline in asthma patients.
- Investigating the impact of specific ADAM33 variants on the progression of asthma.
- Assessing the role of ADAM33 in long-term asthma severity.
Main Methods:
- A longitudinal cohort study of 200 asthma patients over 20 years.
- Analysis of eight single nucleotide polymorphisms (SNPs) within the ADAM33 gene.
- Quantification of the effect of these SNPs on annual decline in forced expiratory volume in one second (FEV1).
Main Results:
- A significant association was found between the rare allele of the S_2 polymorphism and accelerated FEV1 decline.
- The S_2 polymorphism in ADAM33 was linked to a statistically significant (P<0.05) worsening of lung function over time.
- This specific genetic variant indicates a higher risk of rapid lung function deterioration.
Conclusions:
- Findings suggest a specific ADAM33 variant contributes to asthma progression beyond its role in initial development.
- The study highlights ADAM33's potential involvement in enhanced airway remodeling, driving disease progression.
- ADAM33 variants may serve as biomarkers for predicting asthma severity and decline.
More Related Videos
08:44Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
Published on: May 30, 2020
10:21Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
Published on: September 20, 2024
Related Concept Videos
Asthma-I: Introduction
Asthma-III: Symptoms and Complications
Classification of Asthma
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Asthma I: Introduction
Asthma III: Clinical Manifestations
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features