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Local primary (AL) amyloidosis in the palate. A case report

P Stoor1, R Suuronen, C Lindqvist

  • 1Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital, P.O. Box 263, 00029 HUS, Finland.

International Journal of Oral and Maxillofacial Surgery
|May 18, 2004
PubMed

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...