Related Experiment Video
Updated: Aug 24, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
The evolution of HIV and its consequences
Cristian Apetrei1, Preston A Marx, Stephen M Smith
1Tulane National Primate Research Center and Department of Tropical Medicine, Tulane University Health Sciences Center, Covington, LA 70433, USA.
Abstract:
Since the beginning of the AIDS epidemic in 1981, HIV-1 has demonstrated an amazing ability to mutate. HIV-1 was introduced into the human population in the early to mid twentieth century in central Africa. During ensuing decades, this extraordinary mutational capacity has resulted in the circulation of HIV-1 strains that are quite different from one another, yet still remarkably pathogenic. The potential impact of this viral diversity on treatment, monitoring,and vaccine development is discussed.
Related Concept Videos
Viral Mutations
Retrovirus Life Cycles
Sexually Transmitted Infections
Size and Structure of Viral Genomes
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Inhibitors of Virion Maturation and Assembly
