Related Experiment Video
Updated: Aug 24, 2026

Isolation of mRNAs Associated with Yeast Mitochondria to Study Mechanisms of Localized Translation
Published on: March 14, 2014
Messenger RNA stability in mitochondria: different means to an end
Dominique Gagliardi1, Piotr P Stepien, Richard J Temperley
1IBMP CNRS, 12 rue du Général Zimmer, 67084 Strasbourg Cedex, France.
Abstract:
Gene expression is regulated at many stages not merely at the level of transcription. Among the important post-transcriptional processes, RNA turnover has a crucial role. The stability of mRNA in the cytosol of eukarya is increased by the addition of a 3' poly(A) extension. By contrast, this process mediates rapid RNA decay in prokarya. How is mRNA turnover regulated in mitochondria? Their monophyletic, alpha-proteobacterial origin predicts that polyadenylation will induce rapid decay by nucleases and associated factors that are similar to their bacterial ancestors. In this article, however, we report that the regulation of mitochondrial mRNA turnover in diverse species is surprisingly different.
Related Concept Videos
RNA Stability
RNA Stability
mRNA Stability and Gene Expression
Cis-acting Elements involved in mRNA stability
mRNA Stability and Gene Expression
Cis-acting Elements involved in mRNA stability
Nuclear Export of mRNA
Nuclear Export of mRNA

