Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Eosinophils and atopic dermatitis.

D Simon1, L R Braathen, H-U Simon

  • 1Department of Dermatology, Inselspital, University of Bern, CH-3010 Bern, Switzerland.

Allergy
|May 19, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Treatment of linear scleroderma with water-filtered infrared-A irradiation].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2007
Same author

Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A).

Cell death and differentiation·2007
Same author

Pharmacological inhibition of GSK-3 is not strictly correlated with a decrease in tyrosine phosphorylation of residues 216/279.

Journal of neuroscience research·2007
Same author

Type 2 diabetes mellitus: epidemiology, pathophysiology, unmet needs and therapeutical perspectives.

Diabetes & metabolism·2007
Same author

Density functional study of structural and electronic properties of small bimetallic silver-nickel clusters.

The journal of physical chemistry. A·2007
Same author

Increased lipopolysaccharide-induced tumour necrosis factor-alpha, interferon-gamma and interleukin-10 production in atopic dermatitis.

The British journal of dermatology·2007
Same journal

Route of Allergen Immunotherapy: A Global Look Into Physicians' Motivations.

Allergy·2026
Same journal

Dendritic Cell α-Ketoglutarate Regulates Tfh Polarization in Allergy.

Allergy·2026
Same journal

Decoding the "Metallic" Immune Imprint: Single-Cell Exposomics Reveals the Immune Imprint of Fire Smoke.

Allergy·2026
Same journal

Immunonutrition in Early Life: The Role of Complementary Feeding, Dietary Patterns, and Nutritional Exposures on the Health of Young Children-An EAACI Scoping Review.

Allergy·2026
Same journal

Detergent-Containing Toothpaste Decreases Esophageal Mucosal Impedance and Alters Salivary Properties in Humans.

Allergy·2026
Same journal

Global Variation in Timing of Allergenic Food Introduction for Food Allergy Prevention: An International Survey of Healthcare Professionals.

Allergy·2026
See all related articles

Atopic dermatitis (AD) pathogenesis involves eosinophils and interleukin-5 (IL-5). Elevated eosinophil activity and IL-5 point to their crucial role in AD, suggesting IL-5 as a potential therapeutic target.

Area of Science:

  • Immunology
  • Dermatology
  • Pathogenesis of skin diseases

Background:

  • Atopic dermatitis (AD) pathogenesis remains incompletely understood despite advances in immunology.
  • Eosinophils are consistently found in AD inflammatory infiltrates, with elevated blood levels correlating to disease activity.
  • Eosinophil granule proteins, known for cytotoxic effects, are present in AD skin lesions, suggesting their involvement.

Purpose of the Study:

  • To elucidate the role of eosinophils in the pathogenesis of atopic dermatitis.
  • To investigate the significance of T helper 2 cytokines, specifically interleukin-5 (IL-5), in AD.
  • To explore IL-5 as a potential therapeutic target for AD.

Main Methods:

  • Review of existing literature on immunological phenomena in AD.

Related Experiment Videos

  • Analysis of the correlation between eosinophil levels and AD disease activity.
  • Examination of the effects of IL-5 on eosinophil functions.

    • Main Results:

    • Elevated eosinophil numbers and granule protein levels in AD patients correlate with disease severity.
    • Eosinophil granule proteins are deposited in AD skin lesions, indicating direct tissue damage.
    • Increased production of IL-5 in AD is linked to enhanced eosinophilopoiesis, chemotaxis, activation, and reduced apoptosis.

    Conclusions:

    • Eosinophils play a significant role in the pathogenesis of atopic dermatitis.
    • IL-5, a key T helper 2 cytokine, directly influences eosinophil behavior, supporting its involvement in AD.
    • Targeting IL-5 presents a promising avenue for experimental therapies in atopic dermatitis.