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Amyloidosis in the upper aerodigestive tracts
A K Raymond1, N Sneige, J G Batsakis
1University of Texas M. D. Anderson Cancer Center, Houston 77030.
The Annals of Otology, Rhinology, and Laryngology
|September 1, 1992
Summary
Amyloid deposits in the larynx are usually localized and not linked to systemic disease. However, oral and nasopharyngeal amyloidosis often indicates underlying systemic disorders, requiring surgical treatment for laryngeal cases.
Area of Science:
- Otorhinolaryngology
- Pathology
Background:
- Amyloid deposition can occur in the upper aerodigestive tract, including the larynx.
- Laryngeal amyloidosis is frequently a localized condition.
- Oral and nasopharyngeal amyloidosis are often associated with systemic diseases.
Purpose of the Study:
- To differentiate the clinical presentation and associations of laryngeal amyloidosis versus oral and nasopharyngeal amyloidosis.
Main Methods:
- Review of clinical cases and pathological findings of amyloidosis in the upper aerodigestive tract.
Main Results:
- Laryngeal amyloidosis typically presents as a localized condition without systemic involvement.
- Amyloidosis in the oral cavity and nasopharynx commonly signifies underlying systemic disorders.
Conclusions:
- Laryngeal amyloidosis is generally localized and treated with surgery, which may need repetition.
- Oral and nasopharyngeal amyloidosis warrant investigation for systemic predisposing conditions.
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