Related Experiment Video
Updated: Aug 24, 2026
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
Improved detection of lung cancer arising in diffuse lung diseases on chest radiographs using temporal subtraction
Hiroko Okazaki1, Katsumi Nakamura, Hideyuki Watanabe
1Department of Radiology, University of Occupational and Environmental Health, School of Medicine, Japan. Hiroko1.Okazaki@mitsui-chem.co.jp
Rationale And Objectives:
The purpose of this study was to evaluate the usefulness of temporal subtraction for the detection of lung cancer arising in pneumoconiosis, idiopathic pulmonary fibrosis, and pulmonary emphysema.
Materials And Methods:
Fifteen cases of lung cancer arising in diffuse lung diseases, including three cases of pneumoconiosis, six of idiopathic pulmonary fibrosis, and six of pulmonary emphysema, were evaluated. Pathologic proof was obtained by surgery or transbronchial lung biopsy. The average interval between previous and current radiographs was 356 days (range, 31-947 days). All chest radiographs were obtained with a computed radiography system, and temporal subtraction images were produced by subtracting of a previous image from a current one with a nonlinear image-warping technique. The effect of the temporal subtraction image was evaluated by observer performance study with receiver operating characteristic analysis.
Results:
The average observer performance with temporal subtraction was significantly improved (Az = 0.935) compared with that without temporal subtraction (Az = 0.857, P < .0001).
Conclusion:
The temporal subtraction technique is useful for the detection of lung cancer arising in pneumoconiosis, idiopathic pulmonary fibrosis, and pulmonary emphysema.
