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Three-Station Non-Contrast MR Angiography of the Lower Extremities Using Standard and Centric Fresh Blood Imaging
Won C Bae1, Anya Mesa1, Vadim Malis1
1Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA.
Sensors (Basel, Switzerland)
|December 31, 2025
Summary
Centric ky-kz FBI magnetic resonance angiography (MRA) significantly reduces scan time for lower extremity peripheral artery disease (PAD) assessment without compromising diagnostic image quality. This rapid, non-contrast approach improves patient comfort and clinical efficiency.
Area of Science:
- Radiology
- Cardiovascular Imaging
- Medical Physics
Background:
- Peripheral artery disease (PAD) is a common manifestation of atherosclerosis impacting limb perfusion and function.
- Non-contrast magnetic resonance angiography (NC-MRA) offers a safe alternative to contrast-enhanced MRA for PAD detection.
- NC-MRA techniques are crucial for evaluating atherosclerosis in the extremities.
Purpose of the Study:
- To evaluate the efficacy of standard (sFBI) and centric ky-kz (cFBI) fresh blood imaging techniques for rapid, three-station NC-MRA of the lower extremities.
- To compare image quality, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) between sFBI and cFBI sequences.
- To assess the potential of cFBI for reducing scan time in lower extremity MRA.
Main Methods:
- Prospective cross-sectional study involving 10 healthy subjects and 3 PAD patients.
- Acquisition of NC-MRA using sFBI and cFBI sequences at iliac, femoral, and tibial stations on a 3-Tesla MRI system.
- Quantitative and qualitative assessment of image quality, SNR, and CNR, with statistical analysis using repeated-measures ANOVA.
Main Results:
- Image quality was comparable between sFBI and cFBI (p=1.0), though the iliac station showed lower quality (p<0.01).
- cFBI demonstrated superior performance in a PAD patient with an iliac stent, preserving image quality in distal stations where sFBI showed artifacts.
- cFBI reduced total scan time by approximately 40% (291s vs. 468s) but yielded lower SNR (p<0.01) and CNR (p<0.001) compared to sFBI.
Conclusions:
- Three-station non-contrast fresh blood imaging MRA of peripheral arteries is feasible for PAD assessment.
- The cFBI sequence offers significant time savings (approx. 40%) without compromising diagnostic image quality, enhancing clinical utility.
- cFBI provides practical advantages including improved patient comfort and reduced motion artifacts, making it suitable for widespread clinical implementation.
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