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Published on: April 20, 2017
Porphyrin-DNA cross-linking agent hybrids: chemical synthesis and biological studies
Hanping He1, Tian Tian, Ping Wang
1College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, China.
Bioorganic & Medicinal Chemistry Letters
|May 20, 2004
Abstract:
Three new porphyrin-DNA cross-linking conjugates 8, 9, and 10 have been synthesized. Their photoinduced DNA cleavage activity have been studied. The IC(50) values to THP-1 cells in the presence of porphyrin derivatives 8, 9, and 10 with photoirradiation were 5.6, 88.4, and 61.8 nM, respectively.
