Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in thyroid function after bone marrow transplant in young patients.

Masae Matsumoto1, Hiroyuki Ishiguro, Yuichirou Tomita

  • 1Department of Pediatrics, Tokai University School of Medicine, Kanagawa, Japan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|May 21, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical Outcomes of Degenerative Cervical Myelopathy in Patients with Parkinson Disease: A Systematic Review.

Global spine journal·2026
Same author

Posterior cerebellar degeneration associates with executive dysfunction in multiple system atrophy: a voxel-based and atlas-based morphometric study.

Clinical parkinsonism & related disorders·2026
Same author

Successful Engraftment After Repeat Cord Blood Transplantation Using an Identical Conditioning Regimen for MPS II.

The Tokai journal of experimental and clinical medicine·2026
Same author

Visible Tongue Fasciculations With Electromyographic Denervation in Autopsy-Proven Progressive Supranuclear Palsy Mimicking Amyotrophic Lateral Sclerosis.

Muscle & nerve·2026
Same author

Treosulfan-based conditioning for hematopoietic stem cell transplantation in mucopolysaccharidosis: a pilot study.

International journal of hematology·2026
Same author

Long-term outcomes in the pre-moyamoya stage of <i>RNF213</i>-related vasculopathy presenting with ischaemic stroke or transient ischaemic attack: insights from the NCVC Genome Registry.

The Lancet regional health. Western Pacific·2026

Thyroid function changes after bone marrow transplantation (BMT) in young patients can indicate temporary euthyroid sick syndrome. Long-term monitoring is crucial as overt hypothyroidism may develop years post-BMT.

Area of Science:

  • Endocrinology
  • Hematology
  • Oncology

Background:

  • Bone marrow transplantation (BMT) is a critical treatment for various diseases.
  • Thyroid function changes post-BMT in pediatric patients require thorough investigation.

Purpose of the Study:

  • To evaluate thyroid function alterations in young patients following bone marrow transplantation.
  • To differentiate between transient thyroid dysfunction and long-term hypothyroidism after BMT.

Main Methods:

  • Included 91 pediatric patients (0.6-21 years) undergoing BMT between 1985-1995.
  • Assessed thyroid function via serum FT4, FT3, TSH levels, and TRH stimulation tests.
  • Patients received fractionated-total body irradiation (TBI) and chemotherapy as preconditioning.

Related Experiment Videos

Main Results:

  • No overt hypothyroidism or elevated basal TSH (>10 mU/L) observed.
  • Transient decrease in serum FT3 and peak TSH response post-BMT, normalizing within 1 year.
  • One patient developed primary hypothyroidism, another follicular adenoma years after BMT.

Conclusions:

  • Short-term thyroid function changes post-BMT may represent euthyroid sick syndrome.
  • Overt hypothyroidism can manifest years after BMT, necessitating long-term thyroid function surveillance.