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Published on: August 7, 2017

Prognostic data of the second follow-up in childhood wheezy bronchitis

G Póder1, A Nagy, J Kelemen

  • 1First Department of Pediatrics, Semmelweis Medical University, Budapest, Hungary.

Acta Paediatrica Hungarica
|January 1, 1992
PubMed

Insights

Wheezy bronchitis in children generally has a good prognosis. Bronchial hyperreactivity (B.H.) persisted in most children, but few developed new asthma cases over time.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology

Background:

  • Wheezy bronchitis in early childhood is common.
  • Long-term outcomes and predictors require further investigation.

Purpose of the Study:

  • To assess the long-term prognosis of wheezy bronchitis.
  • To evaluate the persistence of bronchial hyperreactivity (B.H.) and asthma development.
  • To explore associations with familial atopy and smoking.

Main Methods:

  • Longitudinal observation of 206 children with early-onset wheezy bronchitis.
  • Acetylcholine challenge testing to assess bronchial hyperreactivity (B.H.).
  • Follow-up assessments including asthma diagnosis, skin prick tests (SPT), and family history collection.

Main Results:

  • 15% of children exhibited bronchial hyperreactivity (B.H.) 9 years post-episode; 9 developed asthma.
  • B.H. persisted in most cases; few new asthma cases emerged in later follow-ups.
  • No significant changes in SPT positivity; familial smoking was more prevalent in the B.H. group but not significantly influential.

Conclusions:

  • Wheezy bronchitis typically has a favorable long-term prognosis.
  • Bronchial hyperreactivity (B.H.) often persists, but progression to asthma is uncommon after early childhood.
  • Familial factors like atopy and smoking showed no significant correlation with B.H. or SPT positivity in this cohort.

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