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Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

Jin-Biao Ma1, Keqiong Ye1, Dinshaw J Patel1

  • 1Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York 10021, USA.

Nature
|May 21, 2004
PubMed
Summary

Small interfering RNA (siRNA) end-binding by the PAZ domain is crucial for RNA silencing. This structural study reveals how PAZ anchors siRNA duplexes, facilitating gene silencing pathways.

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