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Published on: May 21, 2019
Visible-Light-Induced Metallaphotoredox-Catalyzed Synthesis of β-Cyanoketones Using Aryl Acetonitriles and
Mayank Murthy1, Shiv Chand1, Saurabh Kumar1
1Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi221005, India.
Abstract:
A visible-light-driven metallaphotoredox strategy has been developed for the synthesis of β-cyanoketones using readily available 2-bromoacetophenones and aryl acetonitriles under dual eosin Y/Co(OAc)2·4H2O catalysis in the presence of DBU and blue LED irradiation. This operationally simple and mild protocol enables efficient C-C bond formation via a radical pathway, affording synthetically valuable β-cyanoketones in high yields with broad functional-group tolerance.
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