Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Management of Insomnia01:19

Management of Insomnia

688
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
688
Blind Procedures02:07

Blind Procedures

13.7K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
13.7K
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

633
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
633
Insomnia01:27

Insomnia

508
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
508
The Placebo Effect01:54

The Placebo Effect

6.9K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.9K
Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

1.6K
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying major life events associated with insomnia disorder: Stressors that disrupt safety, stability, and identity.

Sleep health·2026
Same author

Discrepancies Between Subjective and Objective Evaluation of Sleep: Potential Marker for Mild Cognitive Impairment.

Sleep medicine research·2026
Same author

Solubility, speciation and thermodynamics of Fe in reducing aqueous KCl solutions.

RSC advances·2025
Same author

Once-Nightly Sodium Oxybate Meets American Academy of Sleep Medicine Criteria for Treatment of Narcolepsy.

Journal of sleep research·2025
Same author

A randomized controlled trial of telemedicine CBTI and PUMAS for prenatal insomnia: Reducing nocturnal cognitive arousal is a treatment mechanism for alleviating insomnia and depression during pregnancy.

Sleep medicine·2025
Same author

A Mechanistic study assessing difficulty discontinuing chronic hypnotic use.

Psychopharmacology·2025

Related Experiment Video

Updated: Feb 19, 2026

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
04:59

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

Published on: May 30, 2025

1.7K

Measuring treatment efficacy in insomnia.

Thomas Roth1

  • 1Henry Ford Hospital Sleep Center, Detroit, MI, USA. troth1@hfhs.org

The Journal of Clinical Psychiatry
|May 22, 2004
PubMed
Summary

Measuring insomnia treatment effectiveness has changed, moving beyond subjective sleep reports to include objective validation and daytime functioning. Future research will focus on broader outcomes like alertness and reduced pain.

Area of Science:

  • Sleep Medicine
  • Clinical Psychology
  • Pharmacology

Background:

  • Historically, insomnia treatment efficacy relied on subjective patient reports, lacking objective validation.
  • Polysomnography improved objective sleep measurement but often overlooked daytime functioning and comorbid conditions.
  • Current efficacy measures for hypnotics inadequately assess the impact on daily life and co-occurring illnesses.

Purpose of the Study:

  • To review the evolution of insomnia treatment efficacy measurement.
  • To highlight the limitations of historical and current assessment methods.
  • To propose future therapeutic endpoints for insomnia treatment.

Main Methods:

  • Literature review of historical and current practices in measuring insomnia treatment efficacy.

More Related Videos

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.6K
Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.7K

Related Experiment Videos

Last Updated: Feb 19, 2026

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
04:59

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

Published on: May 30, 2025

1.7K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.6K
Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.7K
  • Analysis of the role of polysomnography and patient-reported outcomes.
  • Discussion of the impact of insomnia on comorbid medical and psychiatric conditions.

    • Main Results:

    • Early measures focused on nocturnal sleep, with limited objective validation.
    • Polysomnography enhanced objective sleep assessment but rarely evaluated daytime function.
    • Few studies link hypnotic efficacy to improvements in comorbid conditions or daytime functioning.

    Conclusions:

    • Insomnia treatment efficacy measurement has progressed from subjective to objective methods.
    • Future research should incorporate daytime functioning and impact on comorbid conditions.
    • Novel therapeutic endpoints include enhanced alertness, improved depression outcomes, pain reduction, and lessened hot flash disturbances.