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Updated: Aug 24, 2026

Preparation of Segmented Microtubules to Study Motions Driven by the Disassembling Microtubule Ends
Published on: March 15, 2014
CLIPs for organelle-microtubule interactions
1Dept of Cell Biology, Sciences III, University of Geneva, CH-1211, Geneva 4, Switzerland.
Abstract:
Interactions of intracellular membranes with microtubules play a fundamental role in the dynamic organization of cytoplasmic organelles. The microtubule-based motors kinesin and cytoplasmic dynein are responsible for directed movement of vesicles and organelles, but in vitro assays indicate the existence of another class of proteins linking membranes to microtubules. CLIP-170, a cytoplasmic linker protein that mediates binding of endosomes to microtubules, provides a paradigm for understanding how these proteins may complement the role of motors in regulating microtubule-dependent membrane trafficking.
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