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Updated: Aug 24, 2026
HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
Published on: July 20, 2016
Detection of functional platelet-activating factor receptors on leukemic B cells of chronic lymphocytic leukemic
Y Denizot1, M Donnard, L Guglielmi
1UMR CNRS 6101, Laboratoire d'Hématologie and Service d'Hématologie Clinique et de Thérapie Cellulaire, CHU Dupuytren, Limoges, France. yves.denizot@unilim.fr
Abstract:
Although platelet-activating factor receptors (PAF-R) are reported on normal B cells, few results are available concerning leukemic ones. We demonstrated functional PAF-R on cell and nuclear surfaces of leukemic B cells of chronic lymphocytic leukemic (CLL) patients. Analysis of 102 patients revealed dramatic differences for their membrane PAF-R expression, a result that might be related to their plasma IL-4 levels. In the light of the potent immunoregulatory role of PAF on B cell physiology, it is suggested that the presence or absence of PAF-R on leukemic B cells may profoundly affect their in vivo behavior.
