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[First experience with amniotic membrane transplantation].

P Trittibach1, D Goldblum, B E Frueh

  • 1Department of Ophthalmology, University of Bern, Inselspital, Bern, Switzerland. peter.trittibach@insel.ch

Klinische Monatsblatter Fur Augenheilkunde
|May 27, 2004
PubMed
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Amniotic membrane transplantation (AMT) showed positive outcomes for chronic corneal surface defects and conjunctival fornix reconstruction. This study analyzed 17 AMTs, with 65% achieving favorable results in ocular surface repair and inflammation reduction.

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Tissue Engineering

Context:

  • Amniotic membrane transplantation (AMT) is a surgical procedure utilizing the regenerative properties of the amniotic membrane.
  • Ocular surface diseases, including chronic corneal defects and fornix issues, pose significant challenges in ophthalmology.
  • Evaluating the efficacy of AMT in diverse ocular conditions is crucial for advancing treatment strategies.

Purpose:

  • To retrospectively analyze the outcomes of amniotic membrane transplantation (AMT) at a single university eye clinic over a 12-month period.
  • To assess the effectiveness of AMT in treating chronic corneal surface defects without limbal stem cell deficiency, conjunctival fornix defects, and filtering bleb defects.

Summary:

  • This study evaluated 17 amniotic membrane transplantations (AMTs) in 13 patients across three groups: chronic corneal surface defects (n=8), conjunctival fornix reconstruction (n=7), and filtering bleb defects (n=2).

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  • Overall, 65% of AMTs demonstrated favorable postoperative results after a mean follow-up of 8.7 months.
  • Significant improvements in ocular inflammation were noted in patients with chronic corneal surface defects and conjunctival fornix defects, with 4/8 and 7/7 patients, respectively, showing reduced inflammation.

    • Impact:

    • Amniotic membrane transplantation (AMT) proves effective for chronic corneal surface defects and conjunctival fornix reconstruction, offering a less invasive alternative to mucous membrane grafts.
    • The procedure showed promise in reducing ocular inflammation in specific patient groups.
    • AMT was not successful in cases of filtering bleb defects within this study cohort.