Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A method for simultaneous alignment of multiple protein structures.

Maxim Shatsky1, Ruth Nussinov, Haim J Wolfson

  • 1School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel. maxshats@post.tau.ac.il

Proteins
|May 27, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multisite derivation of a machine learning algorithm using high sensitivity troponin to predict major adverse cardiac events in the emergency department.

International journal of cardiology·2026
Same author

Discriminating physiological from non-physiological interfaces in structures of protein complexes: A community-wide study.

Proteomics·2023
Same author

EvoRator2: Predicting Site-specific Amino Acid Substitutions Based on Protein Structural Information Using Deep Learning.

Journal of molecular biology·2023
Same author

Large-scale genetic characterization of the model sulfate-reducing bacterium, <i>Desulfovibrio vulgaris</i> Hildenborough.

Frontiers in microbiology·2023
Same author

Funneling modulatory peptide design with generative models: Discovery and characterization of disruptors of calcineurin protein-protein interactions.

PLoS computational biology·2023
Same author

A novel contact-free atrial fibrillation monitor: a pilot study.

European heart journal. Digital health·2023
Same journal

Engineered HSP90-MP65 Bivalent Fusion Antigen: A Novel Vaccine Candidate Against Invasive Candidiasis.

Proteins·2026
Same journal

Physics-Based Energy Functions for Computational Protein Design.

Proteins·2026
Same journal

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides.

Proteins·2026
Same journal

Stabilization of Bone Morphogenetic Protein-2 at Physiological pH: Contrasting Roles of CHAPS and Arginine in Aggregation Inhibition.

Proteins·2026
Same journal

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase.

Proteins·2026
Same journal

Generalizing the Gaussian Network Model: Spanning-Tree Thermodynamics Shows Entropy-Driven KRAS Activation.

Proteins·2026
See all related articles

MultiProt is an automated tool for protein structure alignment. It identifies common geometric cores and finds partial alignments, improving upon traditional methods for biological applications.

Area of Science:

  • Structural Biology
  • Bioinformatics
  • Computational Biology

Background:

  • Traditional protein structure alignment methods often rely on pairwise alignments, potentially limiting the scope and accuracy of multiple alignments.
  • Detecting common structural features across multiple protein molecules is crucial for understanding function and evolution.

Purpose of the Study:

  • To introduce MultiProt, a novel, fully automated, and efficient technique for detecting multiple structural alignments of protein structures.
  • To overcome limitations of existing methods by performing simultaneous superpositions for direct multiple alignments.

Main Methods:

  • MultiProt employs simultaneous superpositions of input protein molecules to derive multiple structural alignments.
  • The method efficiently identifies high-scoring partial multiple alignments, accommodating inputs where not all molecules participate.

Related Experiment Videos

Main Results:

  • MultiProt successfully demonstrates known multiple alignments of protein structures.
  • Case studies highlight applications in hinge-bent domain alignment, G-protein functional group identification, binding site analysis, and protein-protein interface alignment.

Conclusions:

  • MultiProt offers a powerful and versatile tool for structural analysis, particularly for order-independent alignments like binding sites and protein-protein interfaces.
  • The automated and efficient nature of MultiProt enhances its utility in various biological and structural research areas.