Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Organizing pains.

Emer M Garry1, Susan M Fleetwood-Walker

  • 1Centre for Neuroscience Research, Division of Veterinary Biomedical Sciences, The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK.

Trends in Neurosciences
|May 29, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Randomized Double-Blind Trial of Pregabalin Versus Placebo in Conjunction With Palliative Radiotherapy for Cancer-Induced Bone Pain.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2015
Same author

The characteristics of physical activity and gait in patients receiving radiotherapy in cancer induced bone pain.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2013
Same author

A fully implantable telemetry system for the chronic monitoring of brain tissue oxygen in freely moving rats.

Journal of neuroscience methods·2011
Same author

Involvement of the melanocortin-1 receptor in acute pain and pain of inflammatory but not neuropathic origin.

PloS one·2010
Same author

Reversal of dose-limiting carboplatin-induced peripheral neuropathy with TRPM8 activator, menthol, enables further effective chemotherapy delivery.

Journal of pain and symptom management·2010
Same author

The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment.

EMBO reports·2010
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
Same journal

The neural basis of laughter.

Trends in neurosciences·2026
See all related articles

Chronic pain involves central sensitization, but neuropathic pain resists common treatments. New research links spinal NMDA receptor function in chronic pain to MAGUK proteins, suggesting different protein complexes may affect distinct pain types.

Area of Science:

  • Neuroscience
  • Pain Research
  • Molecular Biology

Background:

  • Chronic pain is often maintained by central neuronal sensitization.
  • Neuropathic pain, unlike inflammatory pain, is typically resistant to centrally acting analgesics.

Purpose of the Study:

  • To investigate the role of spinal NMDA receptors in chronic pain.
  • To explore the involvement of membrane-associated guanylate kinase (MAGUK) family proteins in pain states.

Main Methods:

  • The study focused on the molecular mechanisms underlying chronic pain.
  • Investigated the interaction between spinal NMDA receptors and MAGUK adaptor proteins.

Main Results:

  • The function of spinal NMDA receptors in chronic pain is dependent on MAGUK family adaptor proteins.

Related Experiment Videos

  • Findings suggest that MAGUK protein complexes may differentially contribute to various pain states.

    • Conclusions:

    • Spinal NMDA receptor complexes involving MAGUK proteins are crucial in chronic pain.
    • This research opens new avenues for understanding and potentially treating distinct types of chronic pain.