Related Experiment Video
Updated: Aug 24, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Lack of relation between imaging and physiology in ostial coronary artery narrowings
Ali Ziaee1, Walter A Parham, Steven C Herrmann
1J. Gerard Mudd Cardiac Catheterization Laboratory, St. Louis University Health Sciences Center, 3635 Vista Avenue at Grand Boulevard, St. Louis, MO 63110-0250, USA.
Abstract:
This study compared ostial lesion angiographic severity with physiologic assessment and showed that, for diameter narrowings >70%, fractional flow reserves were >0.75 in 20 of 25 lesions and >0.75 in 30 of 30 lesions with <70% diameter narrowings. Using fractional flow reserve in all ostial narrowings > or =70% may prevent patients from undergoing unnecessary interventions.
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