Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD1d-restricted T cell pathways at the epithelial-lymphocyte-luminal interface.

Arthur Kaser1, Edward E S Nieuwenhuis, Warren Strober

  • 1Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA 02115, USA.

Journal of Pediatric Gastroenterology and Nutrition
|May 29, 2004
PubMed
Summary

Mucosal-associated lymphoid tissues maintain immune homeostasis. CD1d-restricted T cells are key regulators in mucosal immunity, influencing inflammatory conditions like inflammatory bowel disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of a Druggable Target That Predicts Postoperative Crohn's Disease Recurrence.

Gastroenterology·2026
Same author

Additive effects of common and rare genetic variants on inflammatory bowel disease risk in a cohort with immunodeficiency.

The Journal of allergy and clinical immunology·2026
Same author

Clinical relevance of mosaic variants detected by exome sequencing.

The Journal of allergy and clinical immunology·2026
Same author

Tools and advanced imaging technologies for assessing intestinal epithelial barrier integrity: a systematic review.

American journal of physiology. Gastrointestinal and liver physiology·2026
Same author

Chronic enteritis triggered by diet westernization is driven by epithelial ATG16L1-mediated autophagy.

Autophagy·2025
Same author

Metabolic stress sensing by epithelial RXRα links westernization of diet with Crohn's disease.

Cell metabolism·2025

Area of Science:

  • Immunology
  • Gastroenterology
  • Microbiology

Background:

  • Mucosal-associated lymphoid tissues (MALT) maintain a delicate balance between resisting pathogens and preventing inflammation.
  • Dysregulation in MALT contributes to inflammatory diseases, such as inflammatory bowel disease (IBD).
  • CD1d-restricted T cells are emerging as critical players in mucosal immune responses.

Purpose of the Study:

  • To review recent findings on CD1d-restricted pathways in mucosal compartments.
  • To highlight the role of CD1d-restricted T cells in mucosal immunity.
  • To provide an introduction to the biology of CD1d and CD1d-restricted T cells.

Main Methods:

  • Literature review focusing on recent observations.
  • Analysis of CD1d and CD1d-restricted T cell biology.

Related Experiment Videos

  • Examination of CD1d-restricted pathways in mucosal tissues.

    • Main Results:

    • CD1d-restricted T cells play a significant role in mucosal tissues, including the intestine and lung.
    • These cells are increasingly recognized for their regulatory functions in mucosal immunity.
    • Recent observations shed light on the characteristics of CD1d-1 restricted pathways.

    Conclusions:

    • CD1d-restricted T cells are crucial for immune regulation in mucosal environments.
    • Understanding these pathways is vital for addressing mucosal inflammation and diseases like IBD.
    • Further research into CD1d-restricted responses can inform therapeutic strategies for mucosal disorders.