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Updated: Aug 24, 2026

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
Published on: March 17, 2008
Continuous infusion of medications in very low birth weight infants
C Vanhole1, F Jannes, M Vrancken
1Neonatal Intensive Care Unit, Department of Pediatrics and Pharmacy, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.
Objective:
To develop a safe and accurate method for the administration in the neonatal intensive care unit of several potent medications as a continuous infusion without overloading the infant, especially the very low birth weight (VLBW) infant by diluents.
Method:
The method designed is based on a weight-adapted solution limiting the diluent administration and allowing for a versatile modulation of dose administration. As this method was initially designed for VLBW infants, the point of departure of this method is a standard maximal fluid load of 0.3 ml/h for each medication, delivered in a low compliant circuit with a high-precision syringe driver. Solutions are made for 24 h, which is a compromise between drug stability and repeated pressure drops in the circuit when changing the syringe and administration set. To translate a prescription into a solution a conversion factor is calculated. In addition to the calculation principle, this conversion factor is given for a number of commonly used drugs in neonatal care.
Conclusions:
In our experience, the method described adds to the safety and accuracy of continuous drug administration in neonatal care.
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