Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

StuA is required for cell pattern formation in Aspergillus.

K Y Miller1, J Wu, B L Miller

  • 1Department of Bacteriology and Biochemistry, University of Idaho, Moscow 83843.

Genes & Development
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sexually dimorphic differences in angiogenesis markers predict brain aging trajectories.

bioRxiv : the preprint server for biology·2023
Same author

Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2020
Same author

Dopamine receptor D<sub>4</sub> (DRD<sub>4</sub>) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia.

NeuroImage. Clinical·2019
Same author

Application of quantitative DTI metrics in sporadic CJD.

NeuroImage. Clinical·2014
Same author

Examining the value of lexical retrieval treatment in primary progressive aphasia: two positive cases.

Brain and language·2013
Same author

EFNS task force: the use of neuroimaging in the diagnosis of dementia.

European journal of neurology·2012

The Aspergillus nidulans stunted (stuA) gene is crucial for conidiophore development. Its complex regulation involves multiple transcripts and interactions with bristle (brlA) and abacus (abaA) genes, controlling cell organization.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Mycology

Background:

  • The Aspergillus nidulans conidiophore requires precise spatial organization and cell differentiation.
  • The stunted (stuA) gene product plays a critical role in this developmental process.

Purpose of the Study:

  • To elucidate the complex gene expression patterns of stuA.
  • To investigate the regulatory interactions between stuA, brlA, and abaA in conidiophore development.

Main Methods:

  • Analysis of stuA gene transcription and RNA transcripts (stuA alpha and stuA beta).
  • Investigating gene expression changes during developmental competence.
  • Examining regulatory dependencies on brlA and abaA gene products.

Main Results:

Related Experiment Videos

  • stuA expression involves two distinct transcripts initiated from separate promoters.
  • Both transcripts show a 50-fold increase during developmental competence, with further 15-fold enhancement via regulatory mechanisms.
  • Enhanced stuA expression is cell-type specific and requires functional BrlA.
  • StuA influences AbaA spatial localization, potentially by repressing abaA expression.

Conclusions:

  • stuA gene expression is tightly regulated at transcriptional and post-transcriptional levels.
  • Conidiophore morphogenesis depends on intricate regulatory networks involving stuA, brlA, and abaA.
  • StuA acts as a key regulator in spatial organization and cell type determination during fungal development.