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Updated: Aug 12, 2026
07:51
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
[Antiphospholipid syndrome and pregnancy]
Akusherstvo I Ginekologiia
|June 1, 2004
Summary
Antiphospholipid antibody syndrome (APLS) increases pregnancy risks like fetal death due to antibody effects on placental function. Monitoring uterine artery Doppler waveforms helps predict adverse outcomes in high-risk pregnancies.
Area of Science:
- Reproductive Immunology
- Autoimmune Disorders
- Maternal-Fetal Medicine
Context:
- Antiphospholipid antibody syndrome (APLS) is a multisystem autoimmune disorder.
- Key features include thrombosis, obstetric complications, and thrombocytopenia.
- Specific antiphospholipid antibodies (APLa), such as anticardiolipin antibodies (ACL) and lupus anticoagulant (LA), are linked to recurrent pregnancy loss and thrombosis.
Purpose:
- To elucidate the mechanisms by which APLa contribute to adverse pregnancy outcomes.
- To highlight the diagnostic criteria for APLS in pregnancy.
- To emphasize the predictive value of uterine artery Doppler findings in APLS pregnancies.
Summary:
- APLa interfere with trophoblast invasion, fusion, and hormone production, potentially causing early pregnancy loss.
- Post-placentation, APLa induce a prothrombotic state, leading to decreased placental perfusion and infarction.
- Abnormal uterine artery Doppler waveforms (high resistance index/diastolic notch) are associated with APLa and predict adverse outcomes like pre-eclampsia and intrauterine growth restriction.
Impact:
- Identifies APLa-mediated vasculopathy in placental arteries as a cause of abnormal Doppler findings.
- Establishes a strong association between specific Doppler abnormalities and poor pregnancy outcomes.
- Underscores the necessity of maternal treatment and fetal monitoring for managing high-risk pregnancies affected by APLS.
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