Related Experiment Video
Updated: Aug 2, 2026

Submillisecond Conformational Changes in Proteins Resolved by Photothermal Beam Deflection
Published on: February 18, 2014
Rate description of Fokker-Planck processes with time-dependent parameters
1Universität Augsburg, Institut für Physik, Universitätsstrasse 1, D-86135 Augsburg, Germany.
Abstract:
The reduction of a continuous Markov process with multiple metastable states to a discrete rate process is investigated in the presence of slow time-dependent parameters such as periodic external forces or slowly fluctuating barrier heights. A quantitative criterion is provided under which condition a kinetic description with time-dependent frozen rates applies and nonadiabatic corrections to the frozen rates are obtained. Finally it is shown how the long-time behavior of the underlying continuous process can be retrieved from the knowledge of the discrete process by means of an appropriate random decoration of the discrete states. As a particular example of the presented theory an overdamped bistable Brownian oscillator with periodic driving is discussed.
Related Concept Videos
The Bohr Model
The Integrated Rate Law: The Dependence of Concentration on Time
Maxwell-Boltzmann Distribution: Problem Solving
This distribution function f(v) is defined by saying that the expected number N (v1,v2) of particles with speeds between v1 and v2 is given by
Scaling
Transition State Theory
Fundamental Mathematical Principles in Pharmacokinetics: Rate and Order of Reaction
Pharmacokinetic reactions...

