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Updated: Aug 24, 2026

Isolation and Cultivation of Adult Rat Cardiomyocytes
Published on: October 19, 2017
Regular and alternant spiral waves of contractile motion on rat ventricle cell cultures
Seong-Min Hwang1, Kwon-Hae Yea, Kyoung J Lee
1National Creative Research Initiative Center for Neuro-dynamics and Department of Physics, Korea University, Seoul 136-701, Korea.
Abstract:
We demonstrate that meandering as well as regular spiral waves can form in a well-controlled culture layer of rat ventricle cells and that the meandering spiral wave, in particular, can generate an alternant rhythm. These observations are made possible by a newly developed, noninvasive phase contrast macro-optics that is simple but highly effective in visualizing the contractile motion of the populations of cardiac cells.
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