Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retinoid glucuronides do not interact with retinoid binding proteins.

R G Mehta1, A B Barua, J A Olson

  • 1Laboratory of Pathophysiology, IIT Research Institute, Chicago, IL 60616.

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
|January 1, 1992
PubMed
Summary

Retinoid glucuronides, water-soluble retinoids, may not directly bind to specific proteins. Their biological activity in mammary gland differentiation might be independent of or require metabolism to active forms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tissue pharmacokinetics and pharmacodynamics of AmBisome® (L-AmBis) in uninfected and infected animals and their effects on dosing regimens.

Journal of liposome research·2017
Same author

Identification of a 10/10 matched donor for patients with an uncommon haplotype is unlikely.

HLA·2017
Same author

Modelling the cost-effectiveness of adopting risk-stratified approaches to extended screening intervals in the national diabetic retinopathy screening programme in Scotland.

Diabetic medicine : a journal of the British Diabetic Association·2016
Same author

Use of computer decision support in an antimicrobial stewardship program (ASP).

Applied clinical informatics·2015
Same author

Toxicity and efficacy differences between liposomal amphotericin B formulations in uninfected and Aspergillus fumigatus infected mice.

Medical mycology·2015
Same author

Response to Dr Clearkin.

Eye (London, England)·2014

Area of Science:

  • Biochemistry
  • Cell Biology
  • Endocrinology

Background:

  • Retinoid glucuronides are newly identified water-soluble, biologically active retinoids.
  • Retinoyl glucuronide has shown inhibitory effects on hormone-induced differentiation in mouse mammary gland organ cultures.

Purpose of the Study:

  • To investigate if retinoyl and retinyl glucuronides exert their effects via specific retinoid-binding proteins in mammary glands.
  • To determine the mechanism of action for retinoid glucuronides in mammary gland organ culture.

Main Methods:

  • Utilized mouse mammary gland organ cultures.
  • Assessed the binding of retinoyl glucuronide and retinyl glucuronide to specific cytosolic binding proteins.
  • Examined competition assays for retinoic acid and retinol binding proteins.

Related Experiment Videos

Main Results:

  • Neither retinoyl glucuronide nor retinyl glucuronide competed with retinoic acid or retinol for their respective cytosolic binding proteins.
  • The results suggest a novel mechanism for retinoid glucuronide action.

Conclusions:

  • The biological effects of retinoid glucuronides in mammary glands may be independent of direct binding to known retinoid-binding proteins.
  • Alternatively, retinoid glucuronides might require metabolic activation to bind to these proteins, mediating their action.