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Is immune-mediated complete fetal atrioventricular block reversible by transplacental dexamethasone therapy?

E T Jaeggi1, E D Silverman, S-J Yoo

  • 1Division of Cardiology, The Hospital for Sick Children, Toronto, Canada. edgar.jaeggi@sickkids.ca

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Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...