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Updated: Aug 24, 2026

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
The simplex (differentiated) variant of vulvar intraepithelial neoplasia
Meng-Yueh Hsieh1, Hung-Wen Kuo
1Department of Dermatology, Chang-Gung Memorial Hospital, Kaohsiung, Taiwan.
Background:
The simplex (differentiated) variant of vulvar intraepithelial neoplasia is rarely reported. It is regarded as more likely than "classic" carcinoma in situ to be associated with invasion and can be easily mistaken for benign lesions.
Objective:
The objective was to present a case of simplex variant of vulvar intraepithelial neoplasia in a 67-year-old woman that was initially misdiagnosed as lichen simplex chronicus.
Methods:
A case report is reported and the literature is reviewed.
Results:
Surgical excision with a free margin of 5 mm was performed and no evidence of recurrence was noted during the follow-up period of 6 months.
Conclusion:
The simplex vulvar intraepithelial neoplasia is an easily overlooked premalignant disease, and it can be cured with surgical treatment if diagnosed correctly and early.
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