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Cytotoxic T-lymphocyte antigen 4-immunoglobulin in rheumatoid arthritis

Joel M Kremer1

  • 1The Center for Rheumatology, 1367 Washington Avenue, Albany, NY 12203, USA. jkremer@joint-docs.com

Rheumatic Diseases Clinics of North America
|June 3, 2004
PubMed

It is apparent that the potential to significantly affect the immune response exists through artificial modulation of a system of molecules on the surface of T cells that has been designed to specifically provide on-off switches to support or abrogate the activation of T cells. This approach holds considerable promise because it avoids toxicities associated with cell lysis, while theoretically specifically affecting only those T cells, which are being continuously stimulated to become activated. Although there is presently a paucity of studies in humans on the clinical effects of cytotoxic T-lymphocyte antigen 4-immunoglobulin in patients who have rheumatoid arthritis, the existing studies indicate a clear therapeutic value with this approach.

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