Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional brain changes in presymptomatic Huntington's disease.

Sarah A J Reading1, Adam C Dziorny, Laura A Peroutka

  • 1Department of Psychiatry, Johns Hopkins University, Baltimore, MD 21287, USA. sreading@jhmi.edu

Annals of Neurology
|June 3, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Education Research: Educational Informatics: Characterizing Child Neurology Resident Clinical Experiences Using Electronic Health Record Data.

Neurology. Education·2026
Same author

Variability in Vasoactive Medication use Across Pediatric Intensive Care Units: A PICU Data Collaborative Study, 2010-2022.

Journal of intensive care medicine·2026
Same author

Divergence Between Net Fluid and Weight-Based Evaluation in Calculating Cumulative Fluid Balance.

Critical care explorations·2026
Same author

External Validation, Recalibration, and Extension of a Prediction Model of Early Acute Kidney Injury in Critically Ill Children Using Multicenter Data.

Critical care explorations·2026
Same author

Passive Clinical Decision Support Penetrance: A Comparative Analysis in Two Pediatric Intensive Care Units.

Applied clinical informatics·2026
Same author

Huntingtin (HTT) interactome in regulation of DNA repair/remodeling and RNA processing pathways.

Life science alliance·2026

Presymptomatic individuals with Huntington's disease (HD) show reduced brain activation in specific regions during cognitive tasks. These functional brain changes occur before movement symptoms appear, offering insights into early disease progression.

Area of Science:

  • Neuroscience
  • Genetics
  • Neurology

Background:

  • Huntington's disease (HD) is a genetic neurodegenerative disorder.
  • Early structural brain changes are observed in presymptomatic HD individuals.
  • Functional brain alterations may precede motor symptom onset.

Purpose of the Study:

  • To investigate functional brain changes in presymptomatic HD individuals.
  • To utilize functional magnetic resonance imaging (fMRI) to assess brain activity.
  • To examine corticostriatal circuitry function in early-stage HD.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed.
  • A cognitive "interference" protocol was administered to participants.
  • Presymptomatic HD subjects were compared to matched healthy controls.

Related Experiment Videos

Main Results:

  • Presymptomatic HD subjects exhibited significantly reduced activation in the left anterior cingulate cortex (Brodmann areas 24, 32).
  • This hypoactivation was specific and observed despite normal cognitive performance.
  • Results suggest functional alterations in corticostriatal pathways.

Conclusions:

  • Functional brain changes, specifically reduced anterior cingulate cortex activation, are present in presymptomatic HD.
  • These findings highlight potential early biomarkers for Huntington's disease.
  • Understanding early functional deficits can inform future therapeutic strategies.