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Unimod: Protein modifications for mass spectrometry
David M Creasy1, John S Cottrell
1Matrix Science Ltd., London, UK.
Proteomics
|June 3, 2004
Summary
Unimod is a protein modification database for mass spectrometry. It provides accurate mass difference values for natural and artificial modifications, aiding protein identification and sequencing.
Area of Science:
- Biochemistry
- Analytical Chemistry
- Proteomics
Background:
- Mass spectrometry is crucial for protein analysis.
- Accurate mass data is essential for identifying and sequencing proteins.
- Databases of protein modifications enhance mass spectrometry workflows.
Purpose of the Study:
- To introduce Unimod, a comprehensive database of protein modifications.
- To provide accurate, verifiable mass values for modifications.
- To support mass spectrometry applications like protein identification and de novo sequencing.
Main Methods:
- Compiling data on natural and artificial protein modifications.
- Calculating mass differences based on elemental compositions.
- Ensuring accuracy and verifiability of all data entries.
Main Results:
- Unimod contains a curated collection of protein modification masses.
- Values are derived from precise elemental compositions.
- The database facilitates accurate mass spectrometry data interpretation.
Conclusions:
- Unimod serves as a valuable resource for proteomics research.
- It improves the reliability of protein identification and sequencing using mass spectrometry.
- The database supports advancements in understanding protein function and regulation.