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Updated: Aug 24, 2026
Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
Published on: June 8, 2019
Fate of collateral vessels following subintimal angioplasty
Evan C Lipsitz1, Takao Ohki, Frank J Veith
1Department of Surgery, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York, USA. Elipsitz@aol.com
Purpose:
To evaluate the fate of collateral vessels adjacent to and within the target lesion following subintimal angioplasty (SIA).
Methods:
Pre and postprocedural angiograms were reviewed for 29 patients undergoing SIA of the lower extremity arteries over a 3-year period. The number of patent collateral vessels
Results:
The mean number of patent collaterals in the proximal segment was 1.9 (range 0-4) preprocedurally and 1.4 (range 0-4) postprocedurally (p<0.002). The mean number of patent collaterals in the distal segment was 1.9 (range 0-4) pre-procedurally and 1.0 (range 0-4) postprocedurally (p<0.0001). Previously absent collaterals within the recanalized segment were observed in 4 (14%) of 29 patients post-SIA. The mean number of collateral vessels within all 3 segments (proximal, treated, and distal) was 3.9 collaterals preprocedurally and 2.9 collaterals postprocedurally.
Conclusions:
Some collateral vessels are sacrificed during SIA, but the majority are preserved. In addition, SIA has the potential to open new collaterals within the occluded segment. These collaterals may play an important role should restenosis develop within the target segment.