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Down's syndrome and thyroid dysfunction.

D A Morton, M E Jenkins

    Journal of the National Medical Association
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Children with Down's syndrome (DS) have a high incidence of thyroid autoantibodies, suggesting immunological issues. Physicians should screen for thyroid disease in DS patients with any compatible symptom.

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    Area of Science:

    • Pediatric Endocrinology
    • Immunology
    • Genetics

    Background:

    • Down's syndrome (DS) is associated with various health complications, including endocrine disorders.
    • Thyroid dysfunction is a known concern in the DS population, necessitating careful monitoring.

    Observation:

    • This case report details a child with Down's syndrome and hyperthyroidism.
    • Studies indicate a high prevalence of immunological abnormalities in individuals with DS.
    • Elevated incidence of thyroid autoantibodies is observed in DS, yet overt thyroid disease is less common than expected.

    Findings:

    • A strong link exists between immunological abnormalities in DS and the development of thyroid dysfunction.
    • The high rate of autoantibodies suggests a predisposition to autoimmune thyroid conditions like Hashimoto's thyroiditis.

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  • Despite the immunological markers, overt clinical thyroid disease is surprisingly infrequent in many DS individuals.

    • Implications:

    • Healthcare providers should maintain a high index of suspicion for thyroid disease in children with DS.
    • Routine thyroid palpation during physical examinations is crucial for early detection.
    • Further research is needed to understand the discrepancy between high autoantibody prevalence and lower rates of overt disease in DS.