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Dapsone hypersensitivity syndrome masquerading as a viral exanthem: three cases and a mini-review
Introduction:
We report 3 cases of dapsone hypersensitivity syndrome due to anti-malarial chemoprophylactic treatment with maloprim, in military servicemen, presenting like a viral exanthem.
Clinical Picture:
Three male military recruits presented with fever and rash, 6 to 8 weeks after commencing on weekly doses of maloprim.
Treatment:
A course of topical and systemic corticosteroids and oral antihistamines were started.
Outcome:
All cases showed gradual resolution of fever, rash and eventual normalisation of liver function test.
Conclusion:
A high index of suspicion was required before this uncommon syndrome can be recognised. Early institution of corticosteroid therapy and discontinuation of maloprim are the mainstays of treatment.
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