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B cell-dependent T cell development

M Cascalho1, J L Platt

  • 1Transplantation Biology, Mayo Clinic, Rochester, Minnesota 55905, USA. cascalho.marilia@mayo.edu

Acta Paediatrica (Oslo, Norway : 1992). Supplement
|June 5, 2004
PubMed

T and B cells are thought to develop independently. While it is widely recognized that T cells help B cells in the production of antibodies to protein antigens, less well understood is whether or how B cells contribute to T cell development and function. Defects in cell-mediated immunity in individuals with B cell deficiency and in B cell-deficient mice suggest that B cells contribute to T cell function. The question of whether T cell development is B cell dependent was revisited using two novel mouse strains: mice with monoclonal T cells (MT) and mice with monoclonal compartments of both B and T cells (MBT). It was found that T cell development and thymocyte selection is modified by the presence of B cells. These results suggest that B cells, or B cell products, contribute to thymocyte selection and T cell development.

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