Related Experiment Video
Updated: Aug 24, 2026
Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy
Published on: May 3, 2019
A single-institution Wilms' tumor and localized neuroblastoma series
C Boglino1, A Inserra, S Madafferi
1Division of Surgery, Department of Pathology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy.
Insights
This study compares two Wilms
Area of Science:
- Pediatric Oncology
- Surgical Oncology
- Clinical Trials
Background:
- Wilms' tumor treatment has evolved, with differing international approaches to chemotherapy timing.
- The Société Internationale d'Oncologie Pediatrique (SIOP) emphasizes neoadjuvant chemotherapy, while the National Wilms' Tumor Study (NWTS) focuses on postoperative chemotherapy.
- Comparing these treatment philosophies is crucial for optimizing pediatric cancer care.
Purpose of the Study:
- To compare treatment outcomes for Wilms' tumor based on SIOP and NWTS protocols.
- To analyze specific challenges in Wilms' tumor management, including bilaterality, nephroblastomatosis, partial nephrectomy, and vena cava thrombosis.
- To evaluate the long-term outcomes of resectable neuroblastoma treatment within European cooperative studies.
Main Methods:
- Retrospective analysis of 98 Wilms' tumor cases treated at Bambino Gesù Children's Hospital (1980-1999) using SIOP guidelines.
- Comparison with historical data and North American Cooperative Group approaches for neuroblastoma.
- Inclusion of cases with at least 24 months of follow-up.
Main Results:
- The study will detail the comparative effectiveness of neoadjuvant versus postoperative chemotherapy in Wilms' tumor.
- It will discuss the management and outcomes of complex Wilms' tumor cases.
- It will present findings on neuroblastoma treatment protocols and outcomes.
Conclusions:
- The findings will inform best practices for Wilms' tumor and neuroblastoma treatment.
- Understanding the nuances of different treatment protocols can improve pediatric cancer survival rates.
- This research contributes to the ongoing refinement of international pediatric oncology guidelines.
Abstract:
Since January 1980, 120 children affected by Wilms' tumor have been treated at Bambino Gesù, mostly with multimodality treatment according to Société Internationale d'Oncologie Pediatrique (SIOP) protocols, including chemotherapy, surgery and radiotherapy in selected cases. This treatment approach emphasizes the role of preoperative (neoadjuvant) chemotherapy as opposed to the approach favored by the National Wilms' Tumor Study, which is focused on optimizing postoperative chemotherapy after primary surgery. Thus, using SIOP guidelines, staging occurs at the time of surgery, after chemotherapy administration. These differences will constitute the baseline for a comparison between the two experiences. Bilaterality, nephroblastomatosis, partial nephrectomy in unilateral Wilms' tumor and thrombosis of the vena cava are the main topics discussed. For the present study, the analysis was restricted to 98 consecutive cases diagnosed until December 1999, for whom at least 24 mo of follow-up is available. The more recent experience of treating resectable neuroblastoma in cooperative studies dates back to 1979, when the first Italian Cooperative Group Neuroblastoma protocol was introduced. This experience was continued within the frame of the first Localized Neuroblastoma European Study Group protocol (LNESG 94), and will be compared to North American Cooperative Group approaches and outcomes. Preoperative evaluation of surgical risk factors, intraoperative complications and their management, and long-term outcome will be discussed.
