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Updated: Aug 24, 2026

A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro
Published on: August 27, 2015
Putting the squeeze on mechanotransduction
Brian P Helmke1, Martin A Schwartz
1Department of Biomedical Engineering, University of Virginia, Charlottesville, VA22908, USA.
Abstract:
Both mechanical and chemical stimuli guide tissue function. In a recent paper, Tschumperlin et al. proposed that pressure acting on airway epithelium elicits mechanotransduction not by directly altering biochemical signaling but by regulating extracellular fluid volume to modulate ligand-receptor interactions.
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