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Updated: Aug 24, 2026

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In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
Nitroxide-labeled guanine as an ESR spin probe for structural study of DNA
Akimitsu Okamoto1, Takeshi Inasaki, Isao Saito
1Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University and SORST, Japan Science and Technology Corporation, Kyoto 615-8510, Japan.
Bioorganic & Medicinal Chemistry Letters
|June 5, 2004
Abstract:
A guanine derivative with a covalently linked nitroxide spin label has been devised. The spin label was incorporated into oligodeoxynucleotides by post-synthetic modification. The local environment of a variety of G-rich DNA is detectable by ESR using this spin probe.
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