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IgA monoclonal gammopathy of undetermined significance with peripheral neuropathy
M M Mehndiratta1, K Sen, M Tatke
1Department of Neurology, G.B. Pant Hospital, New Delhi 110002, India. mmehndi@vsnl.com
Abstract:
Monoclonal gammopathy of undetermined significance (MGUS) and peripheral neuropathy may be causally linked. In most cases, the M-protein is of IgG or IgM type. Peripheral neuropathy associated with IgA MGUS is uncommon, and there are limited reports. Here, we report a case of a 55-year-old male who was diagnosed to have symmetrical sensorimotor peripheral neuropathy associated with IgA MGUS with deposits of IgA-monoclonal protein in the myelin sheath.
Insights
Peripheral neuropathy can be linked to monoclonal gammopathy of undetermined significance (MGUS). This case highlights a rare instance of IgA MGUS causing sensorimotor neuropathy with IgA deposits in the myelin sheath.
Area of Science:
- Neurology
- Immunology
- Pathology
Background:
- Monoclonal gammopathy of undetermined significance (MGUS) is a condition where abnormal proteins are produced.
- Peripheral neuropathy is a common complication of MGUS, typically associated with IgG or IgM M-proteins.
Observation:
- Peripheral neuropathy associated with IgA MGUS is rare.
- This report details a 55-year-old male patient presenting with symmetrical sensorimotor peripheral neuropathy.
Findings:
- The patient was diagnosed with IgA MGUS.
- Immunohistochemical analysis revealed deposits of IgA-monoclonal protein within the myelin sheath of peripheral nerves.
Implications:
- This case expands the understanding of the spectrum of peripheral neuropathies associated with MGUS.
- It underscores the importance of considering IgA MGUS in patients with unexplained sensorimotor neuropathy.
- Further research may elucidate the pathogenic mechanisms linking IgA M-proteins to myelin damage.
