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Updated: Aug 24, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Replicative senescence enhances apoptosis induced by pemphigus autoimmune antibodies in human keratinocytes
Xin Wang1, François Brégégère, Yoram Soroka
1The Myers Skin Biochemistry Laboratory, Department of Biological Chemistry, The Hebrew University, GivatRam, Jerusalem 91904, Israel.
Abstract:
We have recently shown that skin lesions of the autoimmune disease pemphigus vulgaris are associated with Fas-mediated apoptosis. Here, we describe the induction of the Fas-dependent apoptosis pathway in cultured keratinocytes by pemphigus vulgaris autoantibodies (PV-IgG), as seen from a variety of cellular, morphological and biochemical parameters. All apoptotic characters appear stronger and faster in aged cultures than in young, showing increased susceptibility of senescent keratinocytes to PV-IgG-mediated apoptotic death and culture lesions. Together with immunosenescence, this phenomenon may explain the late onset of pemphigus disease.
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