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Effects of electroconvulsive therapy on frontal white matter in late-life depression: a diffusion tensor imaging

K Nobuhara1, G Okugawa, T Minami

  • 1Department of Neuropsychiatry, Kansai Medical University, Moriguchi City, Japan. nobuhara@takii.kmu.ac.jp

Neuropsychobiology
|June 5, 2004
PubMed

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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...