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Updated: Aug 12, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
Published on: May 8, 2015
The single-step synthesis of a DNA tetrahedron
Russell P Goodman1, Richard M Berry, Andrew J Turberfield
1University of Oxford, Department of Physics, Clarendon Laboratory, Parks Road, Oxford, UKOX1 3PU. russell.goodman@physics.ox.ac.uk
Abstract:
A tetrahedral nanostructure whose edges are DNA double helices self-assembles spontaneously when four appropriately designed oligonucleotides are annealed together in solution; the ease of synthesis, rigidity, and adaptability of this construct make it a promising candidate as a cage for other large molecules and as a building block for more complicated nanostructures.
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