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Detecting Behavioral Deficits in Rats After Traumatic Brain Injury
Published on: January 30, 2018
Recovery of ambulation after traumatic brain injury
Douglas I Katz1, Daniel K White, Michael P Alexander
1HealthSouth Braintree Rehabilitation Hospital, 250 Pond Street, Braintree, MA 02184, USA. dkatz@bu.edu
Objectives:
To identify variables that are predictive of independent ambulation after traumatic brain injury (TBI) and to define the time course of recovery.
Design:
Retrospective review of consecutive admissions of patients with severe TBI over a 32-month period.
Setting:
Brain injury unit in an acute, inpatient rehabilitation hospital.
Participants:
Of 264 patients screened, 116 met criteria that included the ability to participate in motor and functional evaluation on admission to acute rehabilitation, and the absence of other neurologic disorders or fractures that affect one's ability to ambulate.
Intervention:
Inpatient rehabilitation on a specialized TBI unit by an interdisciplinary team.Main outcome measures Recovery of independent ambulation and time to recover independent ambulation.
Results:
Of eligible patients, 73.3% achieved independent ambulation by latest follow-up (up to 5.1 mo). Patients who achieved independent ambulation were significantly younger (P<.05), had better gait scores on admission (P<.05), and tended to be less severely injured-based on duration of posttraumatic amnesia (PTA; P=.058)-than those who did not ambulate independently. There were no differences in recovery based on neuropathologic profile. Mean time to independent ambulation +/- standard deviation was 5.7+/-4.3 weeks; of those achieving independent ambulation, 82.4% did so by 2 months and 94.1% by 3 months. If not independent by 3 months postinjury, patients had a 13.9% chance of recovery. Multivariate regression analysis generated prediction models for time to independent ambulation, using admission FIM instrument scores and age (38% of variance); initial gait score, loss of consciousness, and age (40% of variance); or initial gait score and PTA (58% of variance), when restricted to just those patients with diffuse axonal injury.
Conclusions:
Most patients with severe TBI achieved independent ambulation; the vast majority did so within 3 months postinjury. Functional measures, injury severity measures, and age can help guide prognosis and expectations for time to recover.
